The young soprano was born in Frankfurt am Main and received her first tuition in singing at the age of 14 during a two-year stay in the USA. After finishing secondary school she studied at the Mozarteum in Salzburg under Kammersängerin Lilian Sukis and KS Elisabeth Wilke, passing her diploma examination with distinction in 2003.
Her stage debut at the Salzburg Festival came as early as 2000 when she sang the First Priestess in Gluck's Iphigénie en Tauride. She has been a prize-winner at various international competitions, among them the Belvedere Singing Competition in Vienna.
In 2002, when she was still a student, she was permanently engaged by Zurich Opera House. There she has been seen as Gretel (Hänsel und Gretel), Elvira (L’Italiana in Algeri), Lisa (La Sonnambula), Musetta (La Bohème) and the First Lady (Die Zauberflöte) among other roles. In 2008, she won great acclaim, both from audiences and the international press, when she took over the role of Christine in Richard Strauss’s Intermezzo at short notice in Daniel Herzog's new production conducted by Peter Schneider. Her performance there earned the following accolade from Holger Noltze in the "FAZ" newspaper: "With clear articulation, great eloquence and the necessary resources Christiane Kohl met the demands of the role, continually switching through all the shades between parlando and singing, and between a well-judged bitchy tone and finely shaped lines."
She is very active in the field of concert music, singing in the Frauenkirche in Dresden, at the Konzerthaus Berlin, the KKL Lucerne, the Tonhalle Zurich, the Konzerthaus Dortmund, the Alte Oper Frankfurt and the Berlin Philharmonic among other top venues. She has worked with conductors like Franz Welser-Möst, Michel Plasson, Marcello Viotti, Adam Fischer, Bernard Haitink and Nello Santi.